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Human invariant NKT cells display alloreactivity instructed by invariant TCR-CD1d interaction and killer Ig receptors

Abstract:

Invariant NKT (iNKT) cells are a subset of highly conserved immunoregulatory T cells that modify a variety of immune responses, including alloreactivity. Central to their function is the interaction of the invariant TCR with glycosphingolipid (GSL) ligands presented by the nonpolymorphic MHC class I molecule CD1d and their ability to secrete rapidly large amounts of immunomodulatory cytokines when activated. Whether iNKT cells, like NK and conventional T cells, can directly display alloreacti...

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Journal:
Journal of Immunology
Volume:
181
Issue:
5
Pages:
3268-3276
Publication date:
2008-09-01
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
101092
Language:
English
Pubs id:
pubs:101092
UUID:
uuid:3a5a81aa-2197-4960-b2c2-dbf9da694605
Local pid:
pubs:101092
Deposit date:
2013-02-20

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