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Journal article

Intrapleural use of tissue plasminogen activator and DNase in pleural infection

Abstract:

BACKGROUND: More than 30% of patients with pleural infection either die or require surgery. Drainage of infected fluid is key to successful treatment, but intrapleural fibrinolytic therapy did not improve outcomes in an earlier, large, randomized trial. METHODS: We conducted a blinded, 2-by-2 factorial trial in which 210 patients with pleural infection were randomly assigned to receive one of four study treatments for 3 days: double placebo, intrapleural tissue plasminogen activator (t-PA) an...

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Publisher copy:
10.1056/NEJMoa1012740

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Journal:
New England Journal of Medicine
Volume:
365
Issue:
6
Pages:
518-526
Publication date:
2011-08-11
DOI:
EISSN:
1533-4406
ISSN:
0028-4793
Source identifiers:
179353
Language:
English
Pubs id:
pubs:179353
UUID:
uuid:3a68b16d-d0c1-4d9d-98fb-aa7a661c8a24
Local pid:
pubs:179353
Deposit date:
2012-12-19

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