Journal article
CD56bright NK cells are enriched at inflammatory sites and can engage with monocytes in a reciprocal program of activation
- Abstract:
-
Human NK cells may be divided into a CD56dim subset and a CD56bright subset. In peripheral blood, CD56dim NK cells dominate, whereas in lymph nodes, CD56bright NK cells are more common. In this study we show that CD56bright NK cells accumulate within inflammatory lesions in a wide variety of clinical diseases affecting several different anatomical sites. We demonstrate that when activated by the monokines IL-12, IL-15, and IL-18, these NK cells promote TNF-α production by CD14+ monocytes in a...
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Bibliographic Details
- Journal:
- Journal of Immunology
- Volume:
- 173
- Issue:
- 10
- Pages:
- 6418-6426
- Publication date:
- 2004-11-15
- ISSN:
-
0022-1767
- Source identifiers:
-
92661
Item Description
- Language:
- English
- Pubs id:
-
pubs:92661
- UUID:
-
uuid:3a782a55-b4dd-4720-bf06-a7aa0d03506e
- Local pid:
- pubs:92661
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2004
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