Thesis
Dissecting tunicamycin biosynthesis: a potent carbohydrate processing enzyme inhibitor
- Abstract:
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Tunicamycin nucleoside antibiotics were the first known to target the formation of peptidoglycan precursor lipid I in bacterial cell wall biosynthesis. They have also been used extensively as inhibitors of protein N-glycosylation in eukaryotes, blocking the biogenesis of early intermediate dolichyl-pyrophosphoryl-N-acetylglucosamine. Despite their unusual structures and useful biological properties, little is known about their biosynthesis. Elucidating the metabolic pathway of tunicamyc...
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Bibliographic Details
- Publication date:
- 2010
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- Oxford University, UK
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:3a7a509d-dba0-4d5b-9a39-a883c872d758
- Local pid:
- ora:4897
- Deposit date:
- 2011-02-04
Terms of use
- Copyright holder:
- Filip Wyszynski
- Copyright date:
- 2010
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