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Dissecting tunicamycin biosynthesis: a potent carbohydrate processing enzyme inhibitor

Abstract:

Tunicamycin nucleoside antibiotics were the first known to target the formation of peptidoglycan precursor lipid I in bacterial cell wall biosynthesis. They have also been used extensively as inhibitors of protein N-glycosylation in eukaryotes, blocking the biogenesis of early intermediate dolichyl-pyrophosphoryl-N-acetylglucosamine. Despite their unusual structures and useful biological properties, little is known about their biosynthesis. Elucidating the metabolic pathway of tunicamyc...

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Chemical Biology
Research group:
Prof. Benjamin G. Davis
Oxford college:
Jesus College
Role:
Author
More by this author
Division:
MPLS
Department:
Chemistry
Role:
Author

Contributors

Division:
MPLS
Department:
Chemistry
Role:
Supervisor
Publication date:
2010
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
Oxford University, UK

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