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mTOR signalling and the regulation of Hoxp3 expression

Abstract:

Regulatory T-cells (Treg) are essential for the establishment of self-tolerance and they can be identified by the expression of FOXP3, the "master" transcription factor for the development of Treg. A number of essential signals, namely TCR engagement, TGFβ, as well as the inhibition of the kinase mTOR, have been shown to be crucial for the induction of FOXP3 in the peripheral immune system. Despite recent progress, the molecular mechanisms for induction of FOXP3 remains elusive due, at lea...

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Institution:
University of Oxford
Division:
MSD
Department:
Pathology Dunn School
Research group:
Prof. Waldmann
Oxford college:
Lincoln College
Role:
Author

Contributors

Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Division:
MSD
Department:
Pathology Dunn School
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:3a828d41-5d57-4737-bd55-8c1596a95096
Deposit date:
2016-11-15

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