Asymmetric synthesis of α-alkylated aldehydes using chiral enamines
Direct generation of enantioenriched mono-α-alkylated aldehydes by intermolecular nucleophilic substitution is a general and long-standing problem in synthesis, and is of importance due to the diverse reactions such aldehydes undergo for introducing asymmetry into molecules.
The work described in this thesis initially details the development of the first lithium amide capable of efficiently converting terminal epoxide into enamine functionality, where the latter also demonstrates eff...Expand abstract
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- Oxford University, UK
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- Naeem Kaka
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