Journal article
De novo mutations in DENR disrupt neuronal development and link congenital neurological disorders to faulty mRNA translation re-initiation.
- Abstract:
-
Disruptions to neuronal mRNA translation are hypothesized to underlie human neurodevelopmental syndromes. Notably, the mRNA translation re-initiation factor DENR is a regulator of eukaryotic translation and cell growth, but its mammalian functions are unknown. Here, we report that Denr influences the migration of murine cerebral cortical neurons in vivo with its binding partner Mcts1, whereas perturbations to Denr impair the long-term positioning, dendritic arborization, and dendritic spine c...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
National Institute for Health Research
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Australian Government
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State Government of Victoria
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Bibliographic Details
- Publisher:
- Elsevier Publisher's website
- Journal:
- Cell Reports Journal website
- Volume:
- 15
- Issue:
- 10
- Pages:
- 2251-2265
- Publication date:
- 2016-05-01
- Acceptance date:
- 2016-04-30
- DOI:
- EISSN:
-
2211-1247
- ISSN:
-
2211-1247
- Pmid:
-
27239039
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:624913
- UUID:
-
uuid:3a98e7a9-979e-407d-8270-6d18aefeb155
- Local pid:
- pubs:624913
- Source identifiers:
-
624913
- Deposit date:
- 2017-12-21
Terms of use
- Copyright holder:
- Pagnamenta et al
- Copyright date:
- 2016
- Notes:
- © 2016 The Author(s). This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
- Licence:
- CC Attribution (CC BY)
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