Journal article
An intronic Flk1 enhancer directs arterial-specific expression via RBPJ-mediated venous repression
- Abstract:
-
Objective—The vascular endothelial growth factor (VEGF) receptor Flk1 is essential for vascular development, but the signaling and transcriptional pathways by which its expression is regulated in endothelial cells remain unclear. Although previous studies have identified 2 Flk1 regulatory enhancers, these are dispensable for Flk1 expression, indicating that additional enhancers contribute to Flk1 regulation in endothelial cells. In the present study, we sought to identify Flk1 enhancers co...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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Authors
Funding
Ludwig Institute for Cancer Research
Ltd
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Bibliographic Details
- Publisher:
- American Heart Association Publisher's website
- Journal:
- Arteriosclerosis, Thrombosis, and Vascular Biology Journal website
- Volume:
- 36
- Pages:
- 1209-1219
- Publication date:
- 2016-01-01
- Acceptance date:
- 2016-03-28
- DOI:
- EISSN:
-
1524-4636
- ISSN:
-
1079-5642
Item Description
- Keywords:
- Pubs id:
-
pubs:614964
- UUID:
-
uuid:3a9f9d37-ae63-48ef-8311-3cdb452a8cd6
- Local pid:
- pubs:614964
- Source identifiers:
-
614964
- Deposit date:
- 2016-04-12
Terms of use
- Copyright holder:
- Sacilotto et al
- Copyright date:
- 2016
- Notes:
-
© 2016 The Authors. Arteriosclerosis, Thrombosis, and Vascular Biology
is published on behalf of the American Heart Association, Inc., by Wolters Kluwer. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in
any medium, provided that the original work is properly cited.
- Licence:
- CC Attribution (CC BY)
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