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Journal article

An intronic Flk1 enhancer directs arterial-specific expression via RBPJ-mediated venous repression

Abstract:

Objective—The vascular endothelial growth factor (VEGF) receptor Flk1 is essential for vascular development, but the signaling and transcriptional pathways by which its expression is regulated in endothelial cells remain unclear. Although previous studies have identified 2 Flk1 regulatory enhancers, these are dispensable for Flk1 expression, indicating that additional enhancers contribute to Flk1 regulation in endothelial cells. In the present study, we sought to identify Flk1 enhancers co...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1161/ATVBAHA.116.307517

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Oxford Ludwig Institute
Role:
Author
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Ludwig Institute for Cancer Research Ltd More from this funder
Publisher:
American Heart Association Publisher's website
Journal:
Arteriosclerosis, Thrombosis, and Vascular Biology Journal website
Volume:
36
Pages:
1209-1219
Publication date:
2016-01-01
Acceptance date:
2016-03-28
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Source identifiers:
614964
Keywords:
Pubs id:
pubs:614964
UUID:
uuid:3a9f9d37-ae63-48ef-8311-3cdb452a8cd6
Local pid:
pubs:614964
Deposit date:
2016-04-12

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