Journal article
Effects of neutralizing antibodies on escape from CD8+ T-cell responses in HIV-1 infection.
- Abstract:
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Despite substantial advances in our knowledge of immune responses against HIV-1 and of its evolution within the host, it remains unclear why control of the virus eventually breaks down. Here, we present a new theoretical framework for the infection dynamics of HIV-1 that combines antibody and CD8(+) T-cell responses, notably taking into account their different lifespans. Several apparent paradoxes in HIV pathogenesis and genetics of host susceptibility can be reconciled within this framework ...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Files:
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(Version of record, pdf, 834.5KB)
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- Publisher copy:
- 10.1098/rstb.2014.0290
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Authors
Funding
+ European Research Council
More from this funder
Funding agency for:
Wikramaratna, P
Grant:
278433-PREDEMICS
+ NIHR Biomedical Research Centre, Oxford
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Funding agency for:
Klenerman, P
Grant:
WT091663MA
+ European Research Council
More from this funder
Funding agency for:
Pybus, O
Grant:
614725-PATHPHYLODYN
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Bibliographic Details
- Publisher:
- Royal Society Publisher's website
- Journal:
- Philosophical Transactions B: Biological Sciences Journal website
- Volume:
- 370
- Issue:
- 1675
- Article number:
- 20140290
- Publication date:
- 2015-08-01
- DOI:
- EISSN:
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1471-2970
- ISSN:
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0962-8436
- Source identifiers:
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531684
Item Description
- Language:
- English
- Keywords:
- Subjects:
- Pubs id:
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pubs:531684
- UUID:
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uuid:3aa434dd-9d16-4b33-91cd-f07f23b5afc9
- Local pid:
- pubs:531684
- Deposit date:
- 2015-08-07
Terms of use
- Copyright holder:
- Wikramaratna et al
- Copyright date:
- 2015
- Notes:
-
Copyright © 2015 The Authors. Published by the Royal Society under the terms of the Creative Commons Attribution
License http://creativecommons.org/licenses/by/4.0/, which permits unrestricted use, provided the original
author and source are credited.
- Licence:
- CC Attribution (CC BY)
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