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Journal article

Immunogenicity and protective efficacy of mycobacterial DNA vaccines incorporating plasmid-encoded cytokines against Mycobacterium bovis.

Abstract:

DNA-based vaccines, alone or in combination with other sub-unit vaccination regimes, represent an alternative to live mycobacterial vaccines for protective immunization against tuberculosis. Here, we have used a murine immunization or Mycobacterium bovis aerosol challenge model to assess the immunogenicity and protective efficacy of mycobacterial DNA vaccines. Mice that received immunization with DNA constructs encoding M. bovis antigen 85A (Ag85-A) and arget(ESAT-6) produced measurable inter...

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Publication status:
Published

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Publisher copy:
10.1038/icb.2010.25

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Jenner Institute
Role:
Author
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Journal:
Immunology and cell biology
Volume:
88
Issue:
6
Pages:
651-657
Publication date:
2010-08-01
DOI:
EISSN:
1440-1711
ISSN:
0818-9641
Source identifiers:
67582

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