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Single-molecule light-sheet imaging of suspended T cells

Abstract:

Adaptive immune responses are initiated by triggering of the T cell receptor. Single-molecule imaging based on total internal reflection fluorescence microscopy at coverslip/basal cell interfaces is commonly used to study this process. These experiments have suggested, unexpectedly, that the diffusional behavior and organization of signaling proteins and receptors may be constrained before activation. However, it is unclear to what extent the molecular behavior and cell state is affected by t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bpj.2018.02.044

Authors


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Role:
Author
ORCID:
0000-0002-7561-1127
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Role:
Author
ORCID:
0000-0002-6692-3663
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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
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Publisher:
Elsevier Publisher's website
Journal:
Biophysical Journal Journal website
Volume:
114
Issue:
9
Pages:
2200-2211
Publication date:
2018-05-08
Acceptance date:
2018-02-02
DOI:
EISSN:
1542-0086
ISSN:
0006-3495
Pmid:
29742413
Language:
English
Keywords:
Pubs id:
848092
Local pid:
pubs:848092
Deposit date:
2020-03-08

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