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Journal article

Advances in the biology of bone metastasis: how the skeleton affects tumor behavior.

Abstract:

It is increasingly evident that the microenvironment of bone can influence the cancer phenotype in many ways that favor growth in bone. The ability of cancer cells to adhere to bone matrix and to promote osteoclast formation are key requirements for the establishment and growth of bone metastases. Several cytokine products of breast cancers (e.g. PTHrP, IL-11, IL-8) have been shown to act upon host cells of the bone microenvironment to promote osteoclast formation, allowing for excessive bone...

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Publication status:
Published

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Publisher copy:
10.1016/j.bone.2010.07.015

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
NDORMS
Role:
Author
Journal:
Bone
Volume:
48
Issue:
1
Pages:
6-15
Publication date:
2011-01-01
DOI:
EISSN:
1873-2763
ISSN:
8756-3282
Source identifiers:
240262
Language:
English
Keywords:
Pubs id:
pubs:240262
UUID:
uuid:3ac27215-6423-4361-8668-b0ed9979c8e2
Local pid:
pubs:240262
Deposit date:
2012-12-19

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