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Thesis

Investigating the role of iASPP in normal prostate development and prostate tumourigenesis

Abstract:

Loss of TP63 expression in the prostate epithelium is a hallmark of invasive prostate cancer. An inability of prostate epithelial cells to undergo apoptosis, a process regulated by both TP63 and TP53, is a feature of their malignant transformation. p53 mutations in prostate cancer are uncommon, being mainly associated with advanced metastatic disease. Therefore it is likely that the inability of wild-type p53 to initiate and execute apoptosis is due to molecular alteratio...

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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Oxford college:
St Hugh's College
Role:
Author

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Role:
Supervisor
Role:
Supervisor
Publication date:
2013
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
Subjects:
UUID:
uuid:3ac3e518-0c81-480f-b981-37ebc73fa0a3
Deposit date:
2016-11-15

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