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Horizontal gene transfer rate is not the primary determinant of observed antibiotic resistance frequencies in Streptococcus pneumoniae

Abstract:

The extent to which evolution is constrained by the rate at which horizontal gene transfer (HGT) allows DNA to move between genetic lineages is an open question, which we address in the context of antibiotic resistance in Streptococcus pneumoniae. We analyze microbiological, genomic, and epidemiological data from the largest-to-date sequenced pneumococcal carriage study in 955 infants from a refugee camp on the Thailand-Myanmar border. Using a unified framework, we simultaneously test prior h...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1126/sciadv.aaz6137

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Big Data Institute
Role:
Author
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Department:
External
Role:
Author
ORCID:
0000-0002-1313-4011
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Publisher:
American Association for the Advancement of Science Publisher's website
Journal:
Science Advances Journal website
Volume:
6
Issue:
21
Article number:
eaaz6137
Publication date:
2020-05-20
Acceptance date:
2020-03-10
DOI:
EISSN:
2375-2548
Language:
English
Keywords:
Pubs id:
1106222
Local pid:
pubs:1106222
Deposit date:
2020-06-24

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