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Journal article

Adaptive sugar sensors in hypothalamic feeding circuits.

Abstract:

Brain glucose sensing is critical for healthy energy balance, but how appropriate neurocircuits encode both small changes and large background values of glucose levels is unknown. Here, we report several features of hypothalamic orexin neurons, cells essential for normal wakefulness and feeding: (i) A distinct group of orexin neurons exhibits only transient inhibitory responses to sustained rises in sugar levels; (ii) this sensing strategy involves time-dependent recovery from inhibition via ...

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Publication status:
Published

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Publisher copy:
10.1073/pnas.0802687105

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Clinical Neurosciences
Role:
Author
Journal:
Proceedings of the National Academy of Sciences of the United States of America
Volume:
105
Issue:
33
Pages:
11975-11980
Publication date:
2008-08-11
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Source identifiers:
272110
Language:
English
Keywords:
Pubs id:
pubs:272110
UUID:
uuid:3adb714e-b265-47a6-bbce-29a4723fdc6f
Local pid:
pubs:272110
Deposit date:
2012-12-19

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