Journal article
Adaptive sugar sensors in hypothalamic feeding circuits.
- Abstract:
-
Brain glucose sensing is critical for healthy energy balance, but how appropriate neurocircuits encode both small changes and large background values of glucose levels is unknown. Here, we report several features of hypothalamic orexin neurons, cells essential for normal wakefulness and feeding: (i) A distinct group of orexin neurons exhibits only transient inhibitory responses to sustained rises in sugar levels; (ii) this sensing strategy involves time-dependent recovery from inhibition via ...
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- Publication status:
- Published
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- Publisher copy:
- 10.1073/pnas.0802687105
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Bibliographic Details
- Journal:
- Proceedings of the National Academy of Sciences of the United States of America
- Volume:
- 105
- Issue:
- 33
- Pages:
- 11975-11980
- Publication date:
- 2008-08-11
- DOI:
- EISSN:
-
1091-6490
- ISSN:
-
0027-8424
- Source identifiers:
-
272110
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:272110
- UUID:
-
uuid:3adb714e-b265-47a6-bbce-29a4723fdc6f
- Local pid:
- pubs:272110
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2008
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