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Non-invasive phenotyping and drug testing in single cardiomyocytes or beta-cells by calcium imaging and optogenetics

Abstract:

Identification of drug induced electrical instability of the heart curtails development, and introduction, of potentially proarrhythmic drugs. This problem usually requires complimentary contact based approaches such as patch-clamp electrophysiology combined with field stimulation electrodes to observe and control the cell. This produces data with high signal to noise but requires direct physical contact generally preventing high-throughput, or prolonged, phenotyping of single cells or tissue...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0174181

Authors


More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM Cardiovascular Medicine
Role:
Author
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Publisher:
Public Library of Science Publisher's website
Journal:
PLoS One Journal website
Volume:
12
Issue:
4
Article number:
e0174181
Publication date:
2017-01-01
Acceptance date:
2017-03-04
DOI:
ISSN:
1932-6203
Source identifiers:
688847
Language:
English
Keywords:
Pubs id:
pubs:688847
UUID:
uuid:3ae37844-658e-4129-b289-8daacf1b5616
Local pid:
pubs:688847
Deposit date:
2017-04-28

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