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Journal article

Genetic predisposition to chronic lymphocytic leukemia is mediated by a BMF super-enhancer polymorphism.

Abstract:

Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We deciphered the causal variant at 15q15.1 and the mechanism by which it influences tumorigenesis. We imputed all possible genotypes across the locus and then mapped highly associated SNPs to areas of chromatin accessibility, evolutionary conservation, and transcription factor binding. SNP rs539846 C>A, the most highly associated variant (p ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2016.07.053

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Role:
Author
ORCID:
0000-0001-7192-2385
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Role:
Author
ORCID:
0000-0001-8809-5195
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Arbib Charitable Fund More from this funder
Spanish Ministry of Science and Innovation More from this funder
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
16
Issue:
8
Pages:
2061-2067
Publication date:
2017-08-01
Acceptance date:
2016-07-20
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pmid:
27524613
Source identifiers:
737690

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