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Hydrodynamic trapping measures the interaction between membrane-associated molecules

Abstract:

How membrane proteins distribute and behave on the surface of cells depends on the molecules’ chemical potential. However, measuring this potential, and how it varies with protein-to-protein distance, has been challenging. Here, we present a method we call hydrodynamic trapping that can achieve this. Our method uses the focused liquid flow from a micropipette to locally accumulate molecules protruding above a lipid membrane. The chemical potential, as well as information about the dimensions ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-018-30285-0

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
Weatherall Insti. of Molecular Medicine
Role:
Author
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Role:
Author
ORCID:
0000-0001-8178-8175
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
RDM
Sub department:
RDM - Investigative Medicine Division
Role:
Author
ORCID:
0000-0002-2280-1170
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Publisher:
Springer Publisher's website
Journal:
Scientific Reports Journal website
Volume:
8
Article number:
12479
Place of publication:
England
Publication date:
2018-08-20
Acceptance date:
2018-07-27
DOI:
EISSN:
2045-2322
ISSN:
2045-2322
Pmid:
30127338
Language:
English
Keywords:
Pubs id:
909856
Local pid:
pubs:909856
Deposit date:
2020-03-08

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