Structure of glycosylated NPC1 luminal domain C reveals insights into NPC2 and Ebola virus interactions.
Niemann-pick type C1 (NPC1) is an endo/lysosomal membrane protein involved in intracellular cholesterol trafficking, and its luminal domain C is an essential endosomal receptor for Ebola and Marburg viruses. We have determined the crystal structure of glycosylated NPC1 luminal domain C and find all seven possible sites are glycosylated. Mapping the disease mutations onto the glycosylated structure reveals a potential binding face for NPC2. Knowledge-based docking of NPC1 onto Ebola viral glyc...Expand abstract
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- Peer reviewed
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- Zhao et al
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- © 2016 The Authors. FEBS Letters published by John Wiley and Sons Ltd on behalf of Federation of European Biochemical Societies. This is an open access article under the terms of the Creative Commons Attribution License.
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