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Structures of three HIV-1 HLA-B*5703-peptide complexes and identification of related HLAs potentially associated with long-term nonprogression.

Abstract:

Long-term nonprogression during acute HIV infection has been strongly associated with HLA-B*5701 or HLA-B*5703. In this study, we present the high resolution crystal structures of HLA-B*5703 complexes with three HIV-1 epitopes: ISPRTLNAW (ISP), KAFSPEVIPMF (KAF-11), and KAFSPEVI (KAF-8). These reveal peptide anchoring at position 2 and their C termini. The different peptide lengths and primary sequences are accommodated by variation in the specific contacts made to the HLA-B*5703, flexibility...

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Publication status:
Published

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Publisher copy:
10.4049/jimmunol.175.4.2459

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Journal:
Journal of Immunology
Volume:
175
Issue:
4
Pages:
2459-2468
Publication date:
2005-08-01
DOI:
EISSN:
1550-6606
ISSN:
0022-1767
Source identifiers:
25359

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