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KIR content genotypes associate with carriage of hepatitis B surface antigen, e antigen and HBV viral load in Gambians

Abstract:
Background Hepatocellular carcinoma (HCC) causes over 800,000 deaths worldwide annually, mainly in low income countries, and incidence is rising rapidly in the developed world with the spread of hepatitis B (HBV) and C (HCV) viruses. Natural Killer (NK) cells protect against viral infections and tumours by killing abnormal cells recognised by Killer-cell Immunoglobulin-like Receptors (KIR). Thus genes and haplotypes encoding these receptors may be important in determining bo... Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1371/journal.pone.0188307

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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International Agency for Research on Cancer More from this funder
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Grant:
MRC Gambia quinquennial budget 2006 -2011
Publisher:
Public Library of Science Publisher's website
Journal:
PLoS ONE Journal website
Volume:
12
Issue:
11
Article number:
e0188307
Publication date:
2017-11-17
Acceptance date:
2017-11-04
DOI:
ISSN:
1932-6203
Source identifiers:
796526
Pubs id:
pubs:796526
UUID:
uuid:3b10555e-db9a-4d67-b184-25a342664ce7
Local pid:
pubs:796526
Deposit date:
2017-11-24

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