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Thesis

Structural investigation of the interaction between glypican-3 and uncoordinated-5

Abstract:

Uncoordinated-5 (Unc5) receptors are known for their function to induce repulsion in axonal and cell migration. Another proposed function is as dependency receptors where withdrawal of their ligands results in apoptosis. Unc5’s interactions with its ligands Netrin and fibronectin leucine-rich transmembrane (FLRT) have been extensively investigated; however, the molecular mechanisms of Unc5 as a switch for repulsive signalling and as a dependency receptor remain elusive. Recent work identif...

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Division:
MSD
Department:
Biochemistry
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
ORCID:
0000-0001-6112-5198
Role:
Supervisor
ORCID:
0000-0001-8627-7526
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Subjects:
UUID:
uuid:3b33c1a0-8fd5-44cd-81e4-a02bb49a63f8
Deposit date:
2020-03-16

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