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KDM4A regulates HIF-1 levels through H3K9me3

Abstract:

Regions of hypoxia (low oxygen) occur in most solid tumours and cells in these areas are the most aggressive and therapy resistant. In response to decreased oxygen, extensive changes in gene expression mediated by Hypoxia-Inducible Factors (HIFs) contribute significantly to the aggressive hypoxic tumour phenotype. In addition to HIFs, multiple histone demethylases are altered in their expression and activity, providing a secondary mechanism to extend the hypoxic signalling response. In this s...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/s41598-017-11658-3

Authors


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Institution:
University of Oxford
Department:
CHEMISTRY
Sub department:
Organic Chemistry
Role:
Author
ORCID:
0000-0001-6906-4510
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Role:
Author
ORCID:
0000-0002-3504-1553
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Role:
Author
ORCID:
0000-0002-3069-0378
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Cancer Research UK More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
7
Issue:
1
Article number:
11094
Place of publication:
England
Publication date:
2017-09-11
Acceptance date:
2017-08-25
DOI:
EISSN:
2045-2322
Pmid:
28894274

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