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Thesis

Investigating the regulation of ZUP1, a novel deubiquitinating enzyme involved in DNA repair, by coupled monoubiquitination

Abstract:

Ubiquitination, a major post-translational modification, is reversed through the action of a large family of specialised proteases termed deubiquitinating enzymes (DUBs). Due to their involvement in key cellular pathways, such as inflammation, the cell cycle and DNA repair, as well as their potential as targets for therapeutic intervention, DUBs are critical to investigate. ZUP1 is a recently discovered DUB with cleavage specificity for lysine-63 conjugated polyubiquitin chains and has been p...

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Division:
MSD
Department:
Biochemistry
Role:
Author

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Role:
Supervisor
Role:
Supervisor
ORCID:
0000-0002-2158-0345
Role:
Examiner
ORCID:
0000-0002-7641-2103
Role:
Examiner
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
University of Oxford

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