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Cytotoxicity of 1-deoxysphingolipid unraveled by genome-wide genetic screens and lipidomics in Saccharomyces cerevisiae

Abstract:

Hereditary sensory and autonomic neuropathy (HSAN) types IA and IC (IA/C) are caused by elevated levels of an atypical class of lipid named 1-deoxysphingolipid (DoxSL). How elevated levels of DoxSL perturb the physiology of the cell and how the perturbations lead to HSAN IA/C are largely unknown. In this study, we show that C26-1-deoxydihydroceramide (C26-DoxDHCer) is highly toxic to the cell, while C16- and C18-DoxDHCer are less toxic. Genome-wide genetic screens and lipidomics revealed the ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1091/mbc.E19-07-0364

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Sub department:
Biochemistry
Role:
Author
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Publisher:
American Society for Cell Biology Publisher's website
Journal:
Molecular Biology of the Cell Journal website
Volume:
30
Issue:
22
Pages:
2814-2826
Publication date:
2019-10-14
Acceptance date:
2019-09-04
DOI:
EISSN:
1939-4586
ISSN:
1059-1524
Pmid:
31509475
Language:
English
Keywords:
Pubs id:
1056141
Local pid:
pubs:1056141
Deposit date:
2020-03-12

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