Journal article icon

Journal article

BMP signaling inhibition in Drosophila secondary cells remodels the seminal proteome and self and rival ejaculate functions

Abstract:

Seminal fluid proteins (SFPs) exert potent effects on male and female fitness. Rapidly evolving and molecularly diverse, they derive from multiple male secretory cells and tissues. In Drosophila melanogaster, most SFPs are produced in the accessory glands, which are composed of ∼1,000 fertility-enhancing "main cells" and ∼40 more functionally cryptic "secondary cells." Inhibition of bone morphogenetic protein (BMP) signaling in secondary cells suppresses secretion, leading to a unique uncoupl...

Expand abstract
Publication status:
Published
Peer review status:
Peer reviewed

Actions


Access Document


Files:
Publisher copy:
10.1073/pnas.1914491116

Authors


More by this author
Role:
Author
ORCID:
0000-0002-9760-6185
More by this author
Role:
Author
ORCID:
0000-0002-3228-5480
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
ORCID:
0000-0001-5278-5354
Expand authors...
Publisher:
National Academy of Sciences Publisher's website
Journal:
Proceedings of the National Academy of Sciences Journal website
Volume:
116
Issue:
49
Pages:
24719-24728
Publication date:
2019-11-18
Acceptance date:
2019-10-22
DOI:
EISSN:
1091-6490
ISSN:
0027-8424
Pmid:
31740617
Source identifiers:
1073390
Language:
English
Keywords:
Pubs id:
pubs:1073390
UUID:
uuid:3b7ed5ee-a5d7-40a1-8359-c94f0844eda8
Local pid:
pubs:1073390
Deposit date:
2019-11-23

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP