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Sympathetic neurons are a powerful driver of myocyte function in cardiovascular disease

Abstract:

Many therapeutic interventions in disease states of heightened cardiac sympathetic activity are targeted to the myocytes. However, emerging clinical data highlights a dominant role in disease progression by the neurons themselves. Here we describe a novel experimental model of the peripheral neuro-cardiac axis to study the neuron’s ability to drive a myocyte cAMP phenotype. We employed a co-culture of neonatal ventricular myocytes and sympathetic stellate neurons from normal (WKY) and pro-...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/srep38898

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More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Oxford college:
Merton College
Role:
Author
British Heart Foundation Centre of Research Excellence More from this funder
Wellcome Trust More from this funder
Publisher:
Springer Nature Publisher's website
Journal:
Scientific Reports Journal website
Volume:
6
Pages:
38898
Publication date:
2016-12-14
DOI:
ISSN:
2045-2322
Subjects:
Pubs id:
pubs:666617
UUID:
uuid:3b84d9d0-7da0-4539-bff1-cb10a1c6ea69
Local pid:
pubs:666617
Deposit date:
2016-12-19

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