Dataset
With No Lysine Kinase 3 (WNK3); A Target Enabling Package
- Documentation:
-
A description of the materials and methods is included within the TEP datasheet. Kinases WNK1-4 regulate cation-chloride cotransporters via phosphorylation of SPAK and OSR1 and thereby control salt homeostasis, cell volume and blood pressure. Gain of function mutations in WNK kinases are found in Gordon’s hypertension syndrome suggesting the WNK pathway as a therapeutic target. WNK3 inhibition in particular has also been shown to reduce cerebral injury after Ischemic stroke. Here we present a...
Expand documentation
- Version:
- 3
Actions
Authors/Creators
Contributors
+ Pinkas, D
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
+ Bufton, J
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
+ Alessi, D
Role:
Researcher
+ Bartual, S
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Structural Genomics Consortium
Role:
Researcher
+ Chen, Z
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
NDM Experimental Medicine
Role:
Researcher
Funding
Bibliographic Details
- Publisher:
- University of Oxford
- Publication date:
- 2018
- Version number:
- 3
Item Description
- Keywords:
- Subjects:
- UUID:
-
uuid:3b89880c-eb81-4ffd-b08d-958d5dcfbc92
- Deposit date:
- 2018-05-08
Related Items
Terms of use
- Copyright date:
- 2018
- Notes:
- This document represents version 3 of the TEP datasheet and includes all updates on the project as of April 2018. For more information about TEPs and the TEP Programme, please visit https://thesgc.org/tep.
Metrics
If you are the owner of this record, you can report an update to it here: Report update to this record