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Superior short-term memory in APOE ε2 carriers across the age range

Abstract:

The Apolipoprotein-E (APOE) gene is now known to be associated with individual differences in cognitive health in ageing. However, while the APOE ε4 allele confers significantly increased risk of developing Alzheimer's disease (AD), the APOE ε2 allele is hypothesized to be protective against the development of AD. This is in line with neuroimaging and pathological findings associated with ε2 APOE allele, which go in the opposite direction to those observed in AD-related path...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.bbr.2020.112918

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
ORCID:
0000-0003-4786-0422
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Experimental Psychology
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Psychiatry
Role:
Author
ORCID:
0000-0001-6111-8318
More by this author
Institution:
University of Oxford
Division:
MSD
Sub department:
Psychiatry
Role:
Author
ORCID:
0000-0001-5762-2802
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Publisher:
Elsevier Publisher's website
Journal:
Behavioural Brain Research Journal website
Volume:
397
Article number:
112918
Publication date:
2020-09-20
Acceptance date:
2020-09-11
DOI:
EISSN:
1872-7549
ISSN:
0166-4328
Pmid:
32961217
Language:
English
Keywords:
Pubs id:
1133559
Local pid:
pubs:1133559
Deposit date:
2020-12-09

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