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HLA*IMP - an integrated framework for imputing classical HLA alleles from SNP genotypes

Abstract:

Motivation: Genetic variation at classical HLA alleles influences many phenotypes, including susceptibility to autoimmune disease, resistance to pathogens and the risk of adverse drug reactions. However, classical HLA typing methods are often prohibitively expensive for large-scale studies. We previously described a method for imputing classical alleles from linked SNP genotype data. Here, we present a modification of the original algorithm implemented in a freely available software suite ...

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Publication status:
Published
Peer review status:
Peer reviewed

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Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Mathematical,Physical & Life Sciences Division - Statistics
Role:
Author
More by this author
Institution:
University of Oxford
Department:
Medical Sciences Division - Clinical Medicine,Nuffield Department of - Wellcome Trust Centre for Human Genetics
Role:
Author
Studienstiftung des deutschen Volkes More from this funder
Engineering and Physical Sciences Research Council More from this funder
Human Frontier Science Program More from this funder
Leverhulme Trust More from this funder
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Publisher:
Oxford University Press Publisher's website
Journal:
Bioinformatics Journal website
Volume:
27
Issue:
7
Pages:
968-972
Publication date:
2011-01-01
DOI:
EISSN:
1460-2059
ISSN:
1367-4803
URN:
uuid:3b8e377f-8ff5-458a-acbf-f97e3844a9a5
Local pid:
ora:6006

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