The lipid-activated two-pore domain K+ channel TREK-1 is resistant to hypoxia: implication for ischaemic neuroprotection.

Journal article

TREK-1 is a member of the two-pore domain potassium (K(2P)) channel family that is mechano-, heat, pH, voltage and lipid sensitive. It is highly expressed in the central nervous system and probably encodes one of the previously described arachidonic acid-activated K(+) channels. Polyunsaturated fatty acids and lysophospholipids protect the brain against global ischaemia. Since both lipids are openers of TREK-1, it has been suggested that this K(2P) channel is directly involved in neuroprotect...

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Authors: Buckler, K; Honoré, E

• Publication status: Published
• Journal: Journal of physiology
• Volume: 562
• Issue: Pt 1
• Pages: 213-222
• Publication date: 2005-01-01
• DOI: 10.1113/jphysiol.2004.077503
• EISSN: 1469-7793
• ISSN: 0022-3751
• Language: English
• Keywords: Electrophysiology; Arachidonic Acid; Animals; Cell Line; Lipids; Patch-Clamp Techniques; Transfection; Hypoxia-Ischemia, Brain; Potassium Channels, Tandem Pore Domain; Humans; Picrates; Ischemic Preconditioning; RNA, Messenger; Membrane Potentials; Mice; Solutions