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Journal article

The lipid-activated two-pore domain K+ channel TREK-1 is resistant to hypoxia: implication for ischaemic neuroprotection.

Abstract:

TREK-1 is a member of the two-pore domain potassium (K(2P)) channel family that is mechano-, heat, pH, voltage and lipid sensitive. It is highly expressed in the central nervous system and probably encodes one of the previously described arachidonic acid-activated K(+) channels. Polyunsaturated fatty acids and lysophospholipids protect the brain against global ischaemia. Since both lipids are openers of TREK-1, it has been suggested that this K(2P) channel is directly involved in neuroprotect...

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Publication status:
Published

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
Journal:
Journal of physiology
Volume:
562
Issue:
Pt 1
Pages:
213-222
Publication date:
2005-01-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Source identifiers:
312263
Language:
English
Keywords:
Pubs id:
pubs:312263
UUID:
uuid:3b9a4505-ee64-4f65-b3d4-95be74b3a410
Local pid:
pubs:312263
Deposit date:
2013-11-17

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