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Design and pre-clinical evaluation of a universal HIV-1 vaccine.

Abstract:

BACKGROUND: One of the big roadblocks in development of HIV-1/AIDS vaccines is the enormous diversity of HIV-1, which could limit the value of any HIV-1 vaccine candidate currently under test. METHODOLOGY AND FINDINGS: To address the HIV-1 variation, we designed a novel T cell immunogen, designated HIV(CONSV), by assembling the 14 most conserved regions of the HIV-1 proteome into one chimaeric protein. Each segment is a consensus sequence from one of the four major HIV-1 clades A, B, C and D,...

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Publication status:
Published

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Publisher copy:
10.1371/journal.pone.0000984

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Journal:
PloS one
Volume:
2
Issue:
10
Pages:
e984
Publication date:
2007-01-01
DOI:
EISSN:
1932-6203
ISSN:
1932-6203
Source identifiers:
19870

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