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Plant cysteine oxidases are dioxygenases that directly enable arginyl transferase-catalysed arginylation of N-end rule targets

Abstract:

Crop yield loss due to flooding is a threat to food security. Submergence-induced hypoxia in plants results in stabilization of group VII ETHYLENE RESPONSE FACTORs (ERF-VIIs), which aid survival under these adverse conditions. ERF-VII stability is controlled by the N-end rule pathway, which proposes that ERF-VII N-terminal cysteine oxidation in normoxia enables arginylation followed by proteasomal degradation. The PLANT CYSTEINE OXIDASEs (PCOs) have been identified as catalysts of this oxidat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/ncomms14690

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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Institution:
University of Oxford
Division:
MPLS
Department:
Chemistry
Sub department:
Organic Chemistry
Role:
Author
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Funding agency for:
Flashman, E
Grant:
Dorothy Hodgkin Fellowship
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Funding agency for:
Hopkinson, R
Grant:
William R. Miller Junior Research Fellowship
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Funding agency for:
Brooks-Bartlett, J
Grant:
EP/G03706X/1
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Funding agency for:
Flashman, E
Grant:
Dorothy Hodgkin Fellowship
More from this funder
Grant:
Graduate Training Center GRK1026 ‘Conformational Transitions in Macromolecular Interactions’ at Halle
Publisher:
Springer Nature Publisher's website
Journal:
Nature Communications Journal website
Volume:
8
Issue:
1
Article number:
14690
Publication date:
2017-03-23
Acceptance date:
2017-01-20
DOI:
ISSN:
2041-1723
Language:
English
Pubs id:
pubs:686626
UUID:
uuid:3bb60751-5d0b-4625-b6c3-7a3be69efaec
Local pid:
pubs:686626
Source identifiers:
686626
Deposit date:
2017-03-22

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