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Identification of a novel HLA B*57 restricted cytotoxic T-lymphocyte epitope within HIV-1 rev.

Abstract:
HLA-B5701 and its related allele B5703 have been shown to be strongly associated with slow HIV-1 disease progression. To elucidate the effect of these alleles fully on disease progression it is essential to identify key HIV-1 epitopes that are restricted by these alleles. Here we describe the identification of a novel HLA-B5701, B5703 restricted epitope within HIV-1 rev, which accounted for up to 25 and 40% of the total cytotoxic T-lymphocyte responses in two patients.
Publication status:
Published

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Journal:
AIDS (London, England)
Volume:
20
Issue:
3
Pages:
462-464
Publication date:
2006-02-01
DOI:
EISSN:
1473-5571
ISSN:
0269-9370
Source identifiers:
21398
Language:
English
Keywords:
Pubs id:
pubs:21398
UUID:
uuid:3bc5ca39-af53-48ac-ab55-5111c5677ffa
Local pid:
pubs:21398
Deposit date:
2012-12-19

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