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Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.

Abstract:

The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene d...

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Publication status:
Published

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Publisher copy:
10.1038/nature06406

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Journal:
Nature
Volume:
450
Issue:
7171
Pages:
887-892
Publication date:
2007-12-01
DOI:
EISSN:
1476-4687
ISSN:
0028-0836
Source identifiers:
88652

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