Journal article
Localization of type 1 diabetes susceptibility to the MHC class I genes HLA-B and HLA-A.
- Abstract:
-
The major histocompatibility complex (MHC) on chromosome 6 is associated with susceptibility to more common diseases than any other region of the human genome, including almost all disorders classified as autoimmune. In type 1 diabetes the major genetic susceptibility determinants have been mapped to the MHC class II genes HLA-DQB1 and HLA-DRB1 (refs 1-3), but these genes cannot completely explain the association between type 1 diabetes and the MHC region. Owing to the region's extreme gene d...
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- Publication status:
- Published
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- Publisher copy:
- 10.1038/nature06406
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Bibliographic Details
- Journal:
- Nature
- Volume:
- 450
- Issue:
- 7171
- Pages:
- 887-892
- Publication date:
- 2007-12-01
- DOI:
- EISSN:
-
1476-4687
- ISSN:
-
0028-0836
- Source identifiers:
-
88652
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:88652
- UUID:
-
uuid:3bd412ab-d1a5-415b-a1d5-6927852d5480
- Local pid:
- pubs:88652
- Deposit date:
- 2012-12-19
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- Copyright date:
- 2007
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