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The regulation and functions of the nuclear RNA exosome complex

Abstract:

The RNA exosome complex is the most versatile RNA-degradation machine in eukaryotes. The exosome has a central role in several aspects of RNA biogenesis, including RNA maturation and surveillance. Moreover, it is emerging as an important player in regulating the expression levels of specific mRNAs in response to environmental cues and during cell differentiation and development. Although the mechanisms by which RNA is targeted to (or escapes from) the exosome are still not fully understood, g...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1038/nrm.2015.15

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Role:
Author
More from this funder
Grant:
WT106994MA
WT088359MA
Medical Research Council More from this funder
Publisher:
Nature Publishing Group Publisher's website
Journal:
Nature Reviews Molecular Cell Biology Journal website
Volume:
17
Pages:
227–239
Publication date:
2016-01-04
DOI:
EISSN:
1471-0080
ISSN:
1471-0072
Source identifiers:
579621
Keywords:
Pubs id:
pubs:579621
UUID:
uuid:3bd78b7a-43c1-431f-b3d0-72e8c147d692
Local pid:
pubs:579621
Deposit date:
2015-12-10

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