Journal article
Glycosylphosphatidylinositol-specific, CD1d-restricted T cells in paroxysmal nocturnal hemoglobinuria.
- Abstract:
-
The mechanism of bone marrow failure (BMF) in paroxysmal nocturnal hemoglobinuria (PNH) is not yet known. Because in PNH the biosynthesis of the glycolipid molecule glycosylphosphatidylinositol (GPI) is disrupted in hematopoietic stem and progenitor cells by a somatic mutation in the PIG-A gene, BMF might result from an autoimmune attack, whereby T cells target GPI in normal cells, whereas PIG-A mutant GPI-negative cells are spared. In a deliberate test of this hypothesis, we have demonstrate...
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- Publication status:
- Published
- Peer review status:
- Peer reviewed
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- Publisher copy:
- 10.1182/blood-2012-11-469353
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Authors
Funding
Associazione Italiana per la Ricerca sul Cancro
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National Institute for Health Research
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Regione Toscana
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Italian Ministry of Education, University and Research
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Imperial Healthcare Charity
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Bibliographic Details
- Publisher:
- American Society of Hematology Publisher's website
- Journal:
- Blood Journal website
- Volume:
- 121
- Issue:
- 14
- Pages:
- 2753-2761
- Publication date:
- 2013-01-01
- Acceptance date:
- 2013-01-23
- DOI:
- EISSN:
-
1528-0020
- ISSN:
-
0006-4971
- Source identifiers:
-
508069
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:508069
- UUID:
-
uuid:3be966d4-88b3-42be-b495-c8b990025b79
- Local pid:
- pubs:508069
- Deposit date:
- 2016-03-09
Terms of use
- Copyright holder:
- American Society of Hematology
- Copyright date:
- 2013
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