Journal article icon

Journal article

Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model.

Abstract:

BACKGROUND: Human regulatory T cells (Treg) offer an attractive adjunctive therapy to reduce current reliance on lifelong, nonspecific immunosuppression after transplantation. Here, we evaluated the ability of ex vivo expanded human Treg to prevent the rejection of islets of Langerhans in a humanized mouse model and examined the mechanisms involved. METHODS: We engrafted human pancreatic islets of Langerhans into the renal subcapsular space of immunodeficient BALB/c.rag2(-/-).cγ(-/-) mice, p...

Expand abstract
Publication status:
Published

Actions


Access Document


Publisher copy:
10.1097/tp.0b013e31829fa271

Authors


Expand authors...
Journal:
Transplantation
Volume:
96
Issue:
8
Pages:
707-716
Publication date:
2013-10-01
DOI:
EISSN:
1534-6080
ISSN:
0041-1337
Source identifiers:
416241

Terms of use


Views and Downloads






If you are the owner of this record, you can report an update to it here: Report update to this record

TO TOP