Journal article
Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model.
- Abstract:
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BACKGROUND: Human regulatory T cells (Treg) offer an attractive adjunctive therapy to reduce current reliance on lifelong, nonspecific immunosuppression after transplantation. Here, we evaluated the ability of ex vivo expanded human Treg to prevent the rejection of islets of Langerhans in a humanized mouse model and examined the mechanisms involved. METHODS: We engrafted human pancreatic islets of Langerhans into the renal subcapsular space of immunodeficient BALB/c.rag2(-/-).cγ(-/-) mice, p...
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- Publication status:
- Published
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- Publisher copy:
- 10.1097/tp.0b013e31829fa271
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Bibliographic Details
- Journal:
- Transplantation
- Volume:
- 96
- Issue:
- 8
- Pages:
- 707-716
- Publication date:
- 2013-10-01
- DOI:
- EISSN:
-
1534-6080
- ISSN:
-
0041-1337
- Source identifiers:
-
416241
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:416241
- UUID:
-
uuid:3bf17327-9b8e-49f3-be60-3819db04e11b
- Local pid:
- pubs:416241
- Deposit date:
- 2013-11-16
Terms of use
- Copyright date:
- 2013
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