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Journal article

Heart regeneration in the Mexican cavefish

Abstract:

Although Astyanax mexicanus surface fish regenerate their hearts after injury, their Pachón cavedwelling counterparts cannot and, instead, form a permanent fibrotic scar, similar to the human heart. Myocardial proliferation peaks at similar levels in both surface fish and Pachón 1 week after injury. However, in Pachón, this peak coincides with a strong scarring and immune response, and ultimately, cavefish cardiomyocytes fail to replace the scar. We identified lrrc10 to be upregulated in surf...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1016/j.celrep.2018.10.072

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
Physiology Anatomy and Genetics
Role:
Author
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More from this funder
Funding agency for:
Killen, A
Grant:
FS/14/73/31107
Publisher:
Elsevier Publisher's website
Journal:
Cell Reports Journal website
Volume:
25
Issue:
8
Pages:
1997-2007.e7
Publication date:
2018-11-20
Acceptance date:
2018-10-19
DOI:
EISSN:
2211-1247
ISSN:
2211-1247
Pubs id:
pubs:945508
UUID:
uuid:3c1e09a0-64b3-4af5-b806-b44812b36ec6
Local pid:
pubs:945508
Deposit date:
2018-11-22

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