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Flt3L controls the development of radiosensitive dendritic cells in the meninges and choroid plexus of the steady-state mouse brain.

Abstract:

Antigen-presenting cells in the disease-free brain have been identified primarily by expression of antigens such as CD11b, CD11c, and MHC II, which can be shared by dendritic cells (DCs), microglia, and monocytes. In this study, starting with the criterion of Flt3 (FMS-like receptor tyrosine kinase 3)-dependent development, we characterize the features of authentic DCs within the meninges and choroid plexus in healthy mouse brains. Analyses of morphology, gene expression, and antigen-presenti...

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Publisher copy:
10.1084/jem.20102657

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Journal:
Journal of experimental medicine
Volume:
208
Issue:
8
Pages:
1695-1705
Publication date:
2011-08-01
DOI:
EISSN:
1540-9538
ISSN:
0022-1007
Source identifiers:
426263
Language:
English
Keywords:
Pubs id:
pubs:426263
UUID:
uuid:3c216759-9915-4617-b972-b8b63d90d8b0
Local pid:
pubs:426263
Deposit date:
2014-07-10

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