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Two-dimensional genome-scan identifies novel epistatic loci for essential hypertension

Abstract:

It is well established that gene interactions influence common human diseases, but to date linkage studies have been constrained to searching for single genes across the genome. We applied a novel approach to uncover significant gene-gene interactions in a systematic two-dimensional (2D) genome-scan of essential hypertension. The study cohort comprised 2076 affected sib-pairs and 66 affected half-sib-pairs of the British Genetics of HyperTension study. Extensive simulations were used to estab...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddl058

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Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
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Institution:
Barts and The London School of Medicine and Dentistry, London
Role:
Author
More by this author
Institution:
Barts and The London School of Medicine and Dentistry, London
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
NDM
Sub department:
Human Genetics Wt Centre
Role:
Author
More by this author
Institution:
Barts and The London School of Medicine and Dentistry, London
Role:
Author
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The UK Medical Research Council More from this funder
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Funding agency for:
Wiltshire, S
Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
15
Issue:
8
Pages:
1365-1374
Publication date:
2006-04-01
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Language:
English
Keywords:
Subjects:
UUID:
uuid:3c2b3fd4-4afb-4579-acc8-d9cbda9dc2b4
Local pid:
ora:1650
Deposit date:
2008-03-14

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