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Journal article

Transiently Activated Human Regulatory T Cells Upregulate BCL-XL Expression and Acquire a Functional Advantage in vivo

Abstract:

Regulatory T cells (Tregs) can control excessive or undesirable immune responses toward autoantigens, alloantigens, and pathogens. In transplantation, host immune responses against the allograft are suppressed through the use of immunosuppressive drugs, however this often results in life-threatening side effects including nephrotoxicity and an increased incidence of cancer and opportunistic infections. Tregs can control graft-vs.-host disease and transplant rejection in experimental models, p...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.3389/fimmu.2019.00889

Authors


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Institution:
University of Oxford
Division:
MSD
Department:
Surgical Sciences
Oxford college:
Exeter College
Role:
Author
ORCID:
0000-0002-8279-7732
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Publisher:
Frontiers Media Publisher's website
Journal:
Frontiers in Immunology Journal website
Volume:
10
Article number:
889
Publication date:
2019-04-24
Acceptance date:
2019-04-05
DOI:
EISSN:
1664-3224
Pmid:
31068951
Source identifiers:
999071
Keywords:
Pubs id:
pubs:999071
UUID:
uuid:3c2c973a-fcb3-4c93-b516-9e1dae1f05ce
Local pid:
pubs:999071
Deposit date:
2019-05-20

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