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Lack of involvement of the autonomic nervous system in early ventilatory and pulmonary vascular acclimatization to hypoxia in humans

Abstract:

The activity within the autonomic nervous system may be altered following sustained exposure to hypoxia, and it is possible that this increase in activity underlies the early acclimatization of both ventilation and the pulmonary vasculature to hypoxia. To test this hypothesis, seven individuals were infused with the ganglionic blocker trimetaphan before and after an 8 h exposure to hypoxia. The short half-life of trimetaphan should ensure that the initial infusion does not affect acclimatizat...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1113/jphysiol.2006.118190

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Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Research group:
Human Respiratory and Exercise Physiology Research Group
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Research group:
Human Respiratory and Exercise Physiology Research Group
Role:
Author
More by this author
Institution:
University of Birmingham
Department:
School of Sport and Exercise Sciences
Role:
Author
More by this author
Institution:
University of Oxford
Division:
MSD
Department:
Physiology Anatomy & Genetics
Role:
Author
More by this author
Institution:
University of Cambridge
Department:
Department of Respiratory Medicine
Role:
Author
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Publisher:
Blackwell Publishing Publisher's website
Journal:
Journal of Physiology Journal website
Volume:
579
Issue:
1
Pages:
215-225
Publication date:
2007-02-01
DOI:
EISSN:
1469-7793
ISSN:
0022-3751
Language:
English
Keywords:
Subjects:
UUID:
uuid:3c40392a-1c0b-48cb-b890-eb808e48081a
Local pid:
ora:1706
Deposit date:
2008-03-14

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