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Journal article

Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice.

Abstract:

(6R)-5,6,7,8-Tetrahydro-biopterin (H(4)B) is essential for the catalytic activity of all NO synthases. The hyperphenylalaninemic mouse mutant (hph-1) displays 90% deficiency of the GTP cyclohydrolase I, the rate-limiting enzyme in H(4)B synthesis. A relative shortage of H(4)B may shift the balance between endothelial NO synthase (eNOS)-catalyzed generation of NO and reactive oxygen species. Therefore, the hph-1 mouse represents a unique model to assess the effect of chronic H(4)B deficiency o...

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Publication status:
Published

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Publisher copy:
10.1161/01.atv.21.4.496

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Journal:
Arteriosclerosis, thrombosis, and vascular biology
Volume:
21
Issue:
4
Pages:
496-502
Publication date:
2001-04-01
DOI:
EISSN:
1524-4636
ISSN:
1079-5642
Source identifiers:
104857

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