Journal article
Reactive oxygen species mediate endothelium-dependent relaxations in tetrahydrobiopterin-deficient mice.
- Abstract:
-
(6R)-5,6,7,8-Tetrahydro-biopterin (H(4)B) is essential for the catalytic activity of all NO synthases. The hyperphenylalaninemic mouse mutant (hph-1) displays 90% deficiency of the GTP cyclohydrolase I, the rate-limiting enzyme in H(4)B synthesis. A relative shortage of H(4)B may shift the balance between endothelial NO synthase (eNOS)-catalyzed generation of NO and reactive oxygen species. Therefore, the hph-1 mouse represents a unique model to assess the effect of chronic H(4)B deficiency o...
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- Publication status:
- Published
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- Publisher copy:
- 10.1161/01.atv.21.4.496
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Bibliographic Details
- Journal:
- Arteriosclerosis, thrombosis, and vascular biology
- Volume:
- 21
- Issue:
- 4
- Pages:
- 496-502
- Publication date:
- 2001-04-01
- DOI:
- EISSN:
-
1524-4636
- ISSN:
-
1079-5642
- Source identifiers:
-
104857
Item Description
- Language:
- English
- Keywords:
- Pubs id:
-
pubs:104857
- UUID:
-
uuid:3c7813f1-ada9-485a-9edd-9dc4a22b89eb
- Local pid:
- pubs:104857
- Deposit date:
- 2012-12-19
Terms of use
- Copyright date:
- 2001
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