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Increased EZH2 expression in prostate cancer is associated with metastatic recurrence following external beam radiotherapy

Abstract:

BACKGROUND: Enhancer of zeste 2 (EZH2) promotes prostate cancer progression. We hypothesized that increased EZH2 expression is associated with postradiotherapy metastatic disease recurrence, and may promote radioresistance. METHODS: EZH2 expression was investigated using immunohistochemistry in diagnostic prostate biopsies of 113 prostate cancer patients treated with radiotherapy with curative intent. Associations between EZH2 expression in malignant and benign tissue in prostate biopsy cores...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1002/pros.23817

Authors


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Oxford NIHR Biomedical Research Centre More from this funder
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Publisher:
Wiley Publisher's website
Journal:
Prostate Journal website
Volume:
79
Issue:
10
Pages:
1079-1089
Publication date:
2019-05-18
Acceptance date:
2019-04-12
DOI:
EISSN:
1097-0045
ISSN:
0270-4137
Source identifiers:
999523
Language:
English
Keywords:
Pubs id:
pubs:999523
UUID:
uuid:3c8bf8c0-8f96-4b33-b2c5-c0ad1e706ccd
Local pid:
pubs:999523
Deposit date:
2019-05-20

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