Regional acidosis locally inhibits but remotely stimulates Ca2+ waves in ventricular myocytes.
AIMS: Spontaneous Ca2+ waves in cardiomyocytes are potentially arrhythmogenic. A powerful controller of Ca2+ waves is the cytoplasmic H+ concentration ([H+]i), which fluctuates spatially and temporally in conditions such as myocardial ischaemia/reperfusion. H+-control of Ca2+ waves is poorly understood. We have therefore investigated how [H+]i co-ordinates their initiation and frequency.Expand abstract
METHODS AND RESULTS: Spontaneous Ca2+ waves were imaged (fluo-3) in rat isolated v...
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- Ford et al
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- © The Author 2017. Published by Oxford University Press on behalf of the European Society of Cardiology. This is an Open Access article distributed under the terms of the Creative Commons Attribution License.
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