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Assessing cellular efficacy of bromodomain inhibitors using fluorescence recovery after photobleaching

Abstract:

BACKGROUND: Acetylation of lysine residues in histone tails plays an important role in the regulation of gene transcription. Bromdomains are the readers of acetylated histone marks, and, consequently, bromodomain-containing proteins have a variety of chromatin-related functions. Moreover, they are increasingly being recognised as important mediators of a wide range of diseases. The first potent and selective bromodomain inhibitors are beginning to be described, but the diverse or unknown func...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1186/1756-8935-7-14

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDORMS
Sub department:
Botnar Research Centre
Oxford college:
Balliol College
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
NDM
Sub department:
Target Discovery Institute
Role:
Author
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Publisher:
BioMed Central Publisher's website
Journal:
Epigenetics and Chromatin Journal website
Volume:
7
Issue:
1
Pages:
14
Publication date:
2014-07-13
Acceptance date:
2014-06-23
DOI:
EISSN:
1756-8935
ISSN:
1756-8935
Source identifiers:
478300
Language:
English
Keywords:
UUID:
uuid:3cce4511-9b4a-45ba-bf65-5f692e816524
Local pid:
pubs:478300
Deposit date:
2014-08-15

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