Thesis
Fine structure of the HIV-1 glycan shield
- Abstract:
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The HIV-1 envelope glycoprotein trimer (Env) is covered by an extensive array of glycans that shield it from immune surveillance. The high density of glycans on the trimer surface imposes steric constraints that limit the actions of glycan processing enzymes, such that multiple under-processed structures remain on specific locations. These oligomannose-type glycans are recognized by broadly neutralizing antibodies (bNAbs) that are not thwarted by the glycan shield but, perhaps paradoxicall...
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Bibliographic Details
- Type of award:
- DPhil
- Level of award:
- Doctoral
- Awarding institution:
- University of Oxford
Item Description
- Language:
- English
- Keywords:
- Subjects:
- UUID:
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uuid:3cec0ef7-c305-411e-a76b-125d5e7e9954
- Deposit date:
- 2017-08-21
Related Items
Terms of use
- Copyright holder:
- Behrens, A
- Copyright date:
- 2017
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