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Fine structure of the HIV-1 glycan shield

Abstract:

The HIV-1 envelope glycoprotein trimer (Env) is covered by an extensive array of glycans that shield it from immune surveillance. The high density of glycans on the trimer surface imposes steric constraints that limit the actions of glycan processing enzymes, such that multiple under-processed structures remain on specific locations. These oligomannose-type glycans are recognized by broadly neutralizing antibodies (bNAbs) that are not thwarted by the glycan shield but, perhaps paradoxicall...

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Division:
MSD
Department:
Biochemistry
Department:
University of Oxford
Role:
Author

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Supervisor
Role:
Supervisor
Type of award:
DPhil
Level of award:
Doctoral
Awarding institution:
University of Oxford
Language:
English
Keywords:
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UUID:
uuid:3cec0ef7-c305-411e-a76b-125d5e7e9954
Deposit date:
2017-08-21

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