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Study of DNA double strand break repair in Dictyostelium discoideum

Abstract:

The homologous recombination (HR) pathway contributes to genome integrity by mediating double strand break (DSB) repair using a homologous DNA sequence as a template. In mammals Rad51 and Brca2 are molecules central to this process. Little is known about HR repair in Dictyostelium. However, research previously conducted on DSB repair using this organism has shown that DSB repair pathways are highly conserved when compared to humans. This encouraged study of HR in this organism. In th...

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Institution:
University of Oxford
Division:
MSD
Department:
Biochemistry
Research group:
Dr. Nicholas Lakin's group
Oxford college:
Corpus Christi College
Role:
Author

Contributors

Division:
MSD
Department:
Biochemistry
Role:
Supervisor
Publication date:
2012
Type of award:
MSc by Research
Level of award:
Masters
Awarding institution:
Oxford University, UK
Language:
English
Keywords:
Subjects:
UUID:
uuid:3d0035a5-6f17-435d-990f-22ec24ec441e
Local pid:
ora:8565
Deposit date:
2014-06-10

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