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Journal article

Association of prolactin receptor (PRLR) variants with prolactinomas

Abstract:

Prolactinomas are the most frequent type of pituitary tumors, which represent 10–20% of all intracranial neoplasms in humans. Prolactinomas develop in mice lacking the prolactin receptor (PRLR), which is a member of the cytokine receptor superfamily that signals via Janus kinase-2-signal transducer and activator of transcription-5 (JAK2-STAT5) or phosphoinositide 3-kinase-Akt (PI3K-Akt) pathways to mediate changes in transcription, differentiation and proliferation. To elucidate the role of t...

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Publication status:
Published
Peer review status:
Peer reviewed

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Publisher copy:
10.1093/hmg/ddy396

Authors


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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Oxford college:
Exeter College
Role:
Author
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Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
More by this author
Institution:
University of Oxford
Division:
Medical Sciences Division
Department:
RDM
Sub department:
OCDEM
Role:
Author
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More from this funder
Grant:
G1000467/2010toC.M.G.,P.J.N.
R.V.T
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Grant:
Fellowship SCAF/15/01 (P.J.N.
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Funding agency for:
Thakker, R
Grant:
Senior Investigator Award (R.V.T.
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Publisher:
Oxford University Press Publisher's website
Journal:
Human Molecular Genetics Journal website
Volume:
28
Issue:
6
Pages:
1023–1037
Publication date:
2018-11-15
Acceptance date:
2018-11-11
DOI:
EISSN:
1460-2083
ISSN:
0964-6906
Pmid:
30445560
Language:
English
Pubs id:
pubs:944208
UUID:
uuid:3d0ff851-00cd-4820-bbf2-3d4cc2d1621f
Local pid:
pubs:944208
Deposit date:
2018-12-07

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